June 25 (Reuters) - Gilead Sciences ( GILD ) has entered
into an option and license deal with Kymera Therapeutics ( KYMR )
to support the development and sales of a class of
cancer drugs, the companies said on Wednesday.
As part of the deal, Gilead would pay as much as $750
million, including up to $85 million upfront, in exchange for an
option to gain global rights to develop, manufacture and sell
Kymera's drug candidates that belong to a class called molecular
glue degraders.
Kymera is also eligible to receive tiered royalties on net
sales of the drugs under the deal.
Compared to traditional cancer drugs that inhibit the action
of an associated protein, Kymera's drugs are designed to
selectively eliminate proteins called CDK2, or cyclin-dependent
kinase 2.
"This mechanism aligns within our oncology scientific
framework where we evaluate therapeutic agents that selectively
target and kill cancer cells with minimal impact on healthy
tissue," said Flavius Martin, executive vice president of
research at Gilead.
Kymera said it would lead all research activities for the
drugs currently tested in preclinical studies and advance it as
a potential treatment for breast cancer and other solid tumors.
The deal with Kymera is expected to reduce Gilead's 2025
profit per share by about two to three cents, the companies
said.