U.S. stocks traded mostly lower midway through trading, with the Dow Jones falling more than 200 points on Monday.

The Dow traded down 0.57% to 38,466.36 while the NASDAQ climbed 0.15% to 16,760.36. The S&P 500 also fell, dropping, 0.20% to 5,266.90.

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Leading and Lagging Sectors

Health care shares rose by 0.7% on Monday.

In trading on Monday, energy shares fell by 2%.

Top Headline

U.S. construction spending declined by 0.1% month-over-month to an annual rate of $2,099 billion in April compared to a 0.2% decline in the previous month and versus market estimates of a 0.2% increase.

Equities Trading UP

Bio-Path Holdings, Inc ( BPTH ). shares shot up 57% to $3.23 after the company announced the presentation of data from its ongoing Phase 2 combination study of prexigebersen for the treatment of acute myeloid leukemia at the ASCO Annual Meeting.

Shares of Microbot Medical Inc ( MBOT ). got a boost, surging 112% to $2.12 after the company received FDA approval to proceed with its pivotal human clinical trial.

GameStop Corp ( GME ). shares were also up, gaining 25% to $28.98 after Roaring Kitty on a Reddit post, shared his position on the stock.

Equities Trading DOWN

CalAmp Corp ( CAMP ). shares dropped 60% to $1.08 after the company announced it entered into a restructuring support agreement to take the company private and has voluntarily initiated proceedings under Chapter 11 of the United States Bankruptcy Code.

Shares of Lattice Semiconductor Corporation ( LSCC ) were down 15% to $63.40 after the company announced an interim CEO following Jim Anderson’s decision to step down as President, CEO and Board member to pursue an opportunity with another company.

CNS Pharmaceuticals, Inc ( CNSP ). was down, falling 32% to $0.1466. CNS Pharmaceuticals ( CNSP ) announced a 1-for-50 reverse stock split.

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Commodities

In commodity news, oil traded down 3.4% to $74.40 while gold traded up 0.6% at $2,360.40.

Silver traded up 0.2% to $30.51 on Monday, while copper rose 0.9% to $4.6450.

Euro zone

European shares were mostly higher today. The eurozone's STOXX 600 rose 0.26%, Germany's DAX rose 0.53% and France's CAC 40 gained 0.10%. Spain's IBEX 35 Index climbed 0.68%, while London's FTSE 100 fell 0.13%.

The HCOB Eurozone manufacturing PMI climbed to 47.3 in May compared to 45.7 in April, while German manufacturing PMI rose to 45.4 in May from 42.5 in April. The S&P Global France manufacturing PMI rose to 46.4 in compared to 45.3 in April, while UK manufacturing PMI gained to 51.2 from 49.1.

Asia Pacific Markets

Asian markets closed mostly higher on Monday, with Japan's Nikkei gaining 1.13%, China's Composite Index falling 0.27%, Hong Kong's Hang Seng Index climbing 1.79% and India's S&P BSE Sensex jumping 3.39%.

The HSBC India Manufacturing PMI fell to 57.5 in May from 58.8 in the prior month, while Caixin China general manufacturing PMI gained to 51.7 in May from 51.4 a month ago. The au Jibun Bank Japan manufacturing PMI rose to 50.4 in May from 49.6 in the earlier month.

Economics

The S&P Global manufacturing PMI rose to 51.3 from prior reading of 50. However, analysts were expecting a reading of 50.9.

U.S. construction spending declined by 0.1% month-over-month to an annual rate of $2,099 billion in April compared to a 0.2% decline in the previous month and versus market estimates of a 0.2% increase.

The ISM manufacturing PMI fell to 48.7 in May versus 49.2 in April, and market expectations of of 49.6.

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