Major Wall Street indices opened slightly lower on Monday as uncertainty persisted regarding peace talks between the United States and Iran. Investors are also bracing for a dense wave of corporate earnings and the upcoming Federal Reserve monetary policy meeting later this week.

The Dow Jones Industrial Average dropped 118.5 points or 0.24% at the open to reach 49,112.2 points, while the SP 500 fell 12.4 points or 0.17% to 7,152.72 points. The Nasdaq Composite also declined by 0.15% or 37 points to 24,799.637 points.

This performance comes as investors balance the impact of geopolitical tensions in the Middle East with expectations for a strong earnings season, focusing specifically on monetary policy signals from the U.S. Federal Reserve.

On the corporate front, investors are awaiting results from five of the "Magnificent Seven" companies, adding significance to a week where the market has priced in robust growth.

Additionally, eyes are turned toward the Federal Reserve's interest rate decision on Wednesday, which may mark the final meeting for Chair Jerome Powell before Kevin Warsh assumes the position in May.