March 13 (Reuters) - Altimmune ( ALT ) said on Thursday
that it plans to test its lead experimental obesity drug,
pemvidutide, to potentially treat alcohol use disorder and
alcohol-associated liver disease.
WHY IT'S IMPORTANT
Pemvidutide belongs to the same class of drugs as Novo Nordisk's
Wegovy and Ozempic and Eli Lilly's ( LLY ) Mounjaro
and Zepbound, known as GLP-1 agonists.
The popular newer diabetes and weight loss drugs are being
tested to treat several additional health conditions, such as
liver diseases, chronic kidney disease and neurological
disorders, as well as alcohol use disorder, as companies try to
move beyond their image of a "lifestyle drug".
Novo's popular Wegovy is already approved for treating a
type of heart disease, while Lilly's Zepbound is approved for
treating sleep apnea.
CONTEXT
In February, researchers reported that Novo Nordisk's
blockbuster diabetes drug, Ozempic, showed improvements in
certain measures of alcohol use disorder during a nine-week
trial.
The Danish drugmaker is also testing semaglutide - sold as
the diabetes drug Ozempic and the obesity drug Wegovy - in
thousands of patients with early-stage Alzheimer's disease, with
results expected in 2025.
WHAT'S NEXT
Altimmune plans to initiate a mid-stage trial testing
pemvidutide for alcohol use disorder in the second quarter and
another mid-stage trial testing it for alcohol-associated liver
disease in the third quarter of this year.
MARKET REACTION
Shares of the company were up 3% in aftermarket trading before
paring gains.