May 2 (Reuters) - AstraZeneca ( AZN ) said on Friday its
triple-combination inhaler Breztri Aerosphere met all main goals
in two late-stage trials for uncontrolled asthma, showing
clinically meaningful improvement in lung function.
The Anglo-Swedish drugmaker's therapy, already approved for
the treatment of Chronic Obstructive Pulmonary Disease or
"smoker's lung", was being compared with a dual-combination
maintenance treatment in the trials.
The results come as AstraZeneca ( AZN ) targets $80 billion in
revenue by 2030, after first-quarter sales this week missed
expectations on weaker oncology drug performance.
Asthma is a common but chronic lung disease that makes
breathing difficult due to inflammation and muscle tightening.
It affected 262 million people and caused 455,000 deaths in
2019, according to the World Health Organization.
"The results from the ... trials are exciting and
demonstrate the potential of
budesonide/glycopyrronium/formoterol to evolve the standard of
care to more effectively treat asthma in a single inhaled triple
therapy," said Alberto Papi, primary investigator of the
studies, referring to the compounds in Breztri Aerosphere.
AstraZeneca ( AZN ) said on Friday it would share detailed results
from the trials with authorities and seek to broaden approvals
for Breztri, which brought in sales of $978 million last year
and competes with GSK's Trelegy Ellipta.