June 4 (Reuters) - Britain's medical costs regulator on
Tuesday recommended Eli Lilly's ( LLY ) weight-loss drug
Mounjaro for some patients with obesity and suggested not
placing a time limit on the medicine's use as it had for rival
Novo Nordisk's Wegovy.
Once approved, the draft recommendations from the National
Institute for Health and Care Excellence (NICE) would provide a
roadmap under which Britain's National Health Service (NHS)
could offer Mounjaro as an alternative to Wegovy.
In its draft roadmap for Mounjaro, known chemically as
tirzepatide and sold in the U.S. for weight loss as Zepbound,
NICE said the drug could be used in patients with a body mass
index (BMI) of at least 35 and at least one weight-related
co-morbidity, such as type 2 diabetes or heart disease.
The regulator last year recommended Wegovy for the same
patient population but said it could only be taken "for a
maximum of two years" through the NHS's specialist weight
management scheme - matching the length patients were on the
drug in Novo's pivotal clinical trial.
NICE's committee found it "was not appropriate to include a
long-term stopping rule for tirzepatide," although it
recommended considering stopping treatment if patients lose less
than 5% of their initial weight after 6 months, according to the
document.
Lilly and Novo are vying to make their drugs more easily
accessible to patient populations globally as they ramp up
production to meet soaring demand and compete in a market that
many analysts now expect to reach $150 billion by the early
2030s.
Both Mounjaro and Wegovy are already available privately in
the UK for patients with a BMI of 30 or over and patients with a
BMI of 27 or more who also have another weight-related health
problem such as high blood pressure.
Outside the U.S., Lilly has launched Mounjaro for obesity in
Britain, Germany, Poland, Saudi Arabia and the United Arab
Emirates, according to the company.
The U.S. Food and Drug Administration reported that two
doses of Mounjaro and Zepbound are now available that were
expected to be in limited supply through the second quarter of
this year.
NICE also recommended use of Mounjaro for patients with a
lower BMI from several ethnic backgrounds including Black
African and South Asian.
The regulator said it expected to finalize the roadmap on
Oct. 30 after a public comment period.