April 18 (Reuters) - Cerevel Therapeutics ( CERE ) said
on Thursday its Parkinson's disease drug improved symptom
control in patients when tested as an add-on therapy, meeting
the main goal in a late-stage study.
The trial, which enrolled 507 adults, tested Cerevel's
tavapadon as an add-on therapy to levodopa, the standard of care
for the nervous system disorder that causes progressive brain
damage and impacts movement.
The disease affects about 1 million people in the United
States.
The results showed that patients using these two drugs
experienced an increase of 1.1 hours in total "on" time without
involuntary and erratic movements, compared to those treated
with levodopa and placebo.
A statistically significant reduction was recorded in "off"
time, periods of sudden spike in symptoms when movement becomes
more difficult.
Patients between the ages of 40 and 80, diagnosed with
Parkinson's disease and experiencing motor fluctuations, were
enrolled in the trial.
The patients were on a stable dose of levodopa for at least
four weeks prior to screening.
The drug developer said it will share additional data from
late-stage trials testing the once-daily treatment tavapadon as
a monotherapy in the second half of 2024.
In December, AbbVie ( ABBV ) agreed to buy Cerevel
Therapeutics ( CERE ) for about $8.7 billion. The deal is expected to
close in the middle of 2024.