June 21 (Reuters) - Overweight patients given an
experimental weight loss drug being developed by China's Sciwind
Biosciences lost an average of 10% to 15% of their body weight,
roughly in line with results from a similar drug sold by Novo
Nordisk , according to a late-stage study published on
Saturday.
The drug, called ecnoglutide, belongs to a class of drugs
that include Novo's Wegovy called GLP-1 receptor agonists, which
work by helping control blood sugar levels and triggering a
feeling of fullness.
"It's going to be competitive," said Dr. Tricia Tan of
Imperial College London, who wrote a piece accompanying the data
which appeared in medical journal The Lancet.
Tan said additional GLP-1s on the market could potentially
drive prices down and improve access globally.
"It's great to have competition in the market. It's been
extremely frustrating - I work in the National Health Service
and patients are not getting access to these drugs."
Patients have seen even better results with Eli Lilly's ( LLY )
Zepbound, which stimulates GLP-1 as well as a second gut
hormone called GIP. More than 20% weight loss was reported in
clinical trials.
According to the Sciwind Phase 3 study, 499 patients were
given 1.2 mg, 1.8 mg or 2.4 mg of ecnoglutide as a subcutaneous
injection once weekly for 48 weeks, with 165 patients assigned
to receive a placebo. The study was conducted at 36 medical
centers across China.
The patients who received the 1.2 mg dose lost an average of
9.9% of their body weight after 48 weeks, and those who received
the 1.8 mg dose lost an average of 13.3% of their body weight.
Patients on the 2.4 mg dose lost an average of 15.4% of their
body weight.
The patients on placebo lost an average of 0.3% of their
body weight over the period.
The side-effect profile is not significantly different from
the other weight loss drugs. Many of the patients given
ecnoglutide experienced decreased appetite and gastrointestinal
problems, including diarrhea, nausea and vomiting, the study
authors wrote.