Feb 21 (Reuters) - A newly discovered bat coronavirus
uses the same cell-surface protein to gain entry into human
cells as the SARS-CoV-2 virus that causes COVID-19, raising the
possibility that it could someday spread to humans, Chinese
researchers have reported.
The virus does not enter human cells as readily as
SARS-CoV-2 does, the Chinese researchers reported in the journal
Cell, noting some of its limitations.
The scientists said that like SARS-CoV-2, the bat virus
HKU5-CoV-2 contains a feature known as the furin cleavage site
that helps it to enter cells via the ACE2 receptor protein on
cell surfaces.
In lab experiments, HKU5-CoV-2 infected human cells with
high ACE2 levels in test tubes and in models of human intestines
and airways.
In further experiments, the researchers identified
monoclonal antibodies and antiviral drugs that target the bat
virus.
Bloomberg, which reported on the study earlier on Friday,
said the paper identifying the bat virus had moved shares of
COVID vaccine makers. Pfizer ( PFE ) shares closed up 1.5% on
Friday, Moderna ( MRNA ) climbed 5.3% and Novavax ( NVAX ) was
up about 1% on a down day for the broader market.
Asked about concerns raised by the report of another
pandemic resulting from this new virus, Dr. Michael Osterholm,
an infectious disease expert at the University of Minnesota,
called the reaction to the study "overblown."
He said there is a lot of immunity in the population to
similar SARS viruses compared with 2019, which may reduce the
pandemic risk.
The study itself noted that the virus has significantly less
binding affinity to human ACE2 than SARS-CoV-2, and other
suboptimal factors for human adaptation suggest the "risk of
emergence in human populations should not be exaggerated."