LONDON, July 5 (Reuters) - Patients with type 2 diabetes
taking GLP-1 treatments, which include Ozempic, have a lower
chance of developing 10 types of obesity-related cancers than
those taking insulin and other diabetes drugs, according to a
study published on Friday.
GLP-1 treatments for type 2 diabetes have been on the market
for nearly 20 years. The newer generation - such as Novo
Nordisk's Ozempic and Eli Lilly's ( LLY ) Mounjaro -
are far more effective at controlling blood sugar levels and
inducing weight loss. Ozempic was the first of the newer
generation in the class to be approved, in 2017.
In the study published on Friday in medical journal JAMA
Network Open, researchers examined the medical records of 1.6
million patients with type 2 diabetes who had no prior history
of 13 types of obesity-related cancers including gallbladder
cancer and kidney cancer.
The study did not specify which GLP-1 medicines the patients
took, but the records were for patients on these medicines or
insulin or the diabetes drug metformin between March 2005 and
November 2018. Ozempic was only approved by the U.S. Food and
Drug Administration in December 2017.
The study found that the patients treated with a GLP-1
therapy instead of insulin "had a significant risk reduction" in
10 of those cancers.
The findings are "preliminary evidence of the potential
benefit" of GLP-1 drugs for cancer prevention in high-risk
population, the researchers concluded. They also said that
studies of the newer generation of these medicines for their
cancer preventative effects are warranted.
The authors of the study did not report having received
funds from drugmakers who market these medicines.
The versions of these medicines that are approved to treat
obesity, and have been shown to help patients lose as much as
20% of their weight on average, have exploded in popularity,
leading to record profits for Novo and Lilly.
Lilly's Mounjaro and weight-loss therapy Zepbound, as well
as Novo's rival medicines Ozempic and Wegovy are already being
studied to see whether they can improve health in many other
ways, ranging from alcohol addiction to sleep apnea.
In March, the U.S. Food and Drug Administration approved
Wegovy for lowering the risk of stroke and heart attack in
overweight or obese adults who do not have diabetes.