LONDON, May 8 (Reuters) - Google Deepmind has
unveiled the third major version of its "AlphaFold" artificial
intelligence model, designed to help scientists design drugs and
target disease more effectively.
In 2020, the company made a significant advance in molecular
biology by using AI to successfully predict the behaviour of
microscopic proteins.
With the latest incarnation of AlphaFold, researchers at
DeepMind and sister company Isomorphic Labs - both overseen by
cofounder Demis Hassabis - have mapped the behaviour for all of
life's molecules, including human DNA.
The interactions of proteins - from enzymes crucial to the
human metabolism, to the antibodies that fight infectious
diseases - with other molecules is key to drug discovery and
development.
DeepMind said the findings, published in research journal
Nature on Wednesday, would reduce the time and money needed to
develop potentially life-changing treatments.
"With these new capabilities, we can design a molecule that
will bind to a specific place on a protein, and we can predict
how strongly it will bind," Hassabis said in a press briefing on
Tuesday.
"It's a critical step if you want to design drugs and
compounds that will help with disease."
The company also announced the release of the "AlphaFold
server", a free online tool that scientists can use to test
their hypotheses before running real-world tests.
Since 2021, AlphaFold's predictions have been freely
accessible to non-commercial researchers, as part of a database
containing more than 200 million protein structures, and has
been cited thousands of times in others' work.
DeepMind said the new server required less computing
knowledge, allowing researchers to run tests with just a few
clicks of a button.
John Jumper, a senior research scientist at DeepMind, said:
"It's going to be really important how much easier the AlphaFold
server makes it for biologists - who are experts in biology, not
computer science - to test larger, more complex cases."
Dr Nicole Wheeler, an expert in microbiology at the
University of Birmingham, said AlphaFold 3 could significantly
speed up the drug discovery pipeline, as "physically producing
and testing biological designs is a big bottleneck in
biotechnology at the moment".