March 23 (Reuters) - Kali Therapeutics said on Monday it
has entered into a licensing agreement with French drugmaker
Sanofi to develop the privately held firm's
experimental treatment for several autoimmune diseases.
Here are the details:
* Under the deal, Sanofi will obtain global rights to KT501,
a tri-specific antibody utilizing Kali Therapeutics' proprietary
discovery and research platform.
* Kali Therapeutics will receive $180 million in upfront and
near-term payments and is eligible for up to $1.05 billion in
development and commercial milestone payments.
* If the drug is approved, the company will also receive
tiered royalties on product sales ranging from the high-single
digits to double digits.
* KT501 is currently being tested in an early-stage study in
rheumatoid arthritis patients to assess its safety and how well
the drug was tolerated.
* Studies in non-human primatesshowed KT501 strongly
reduced a type of white blood cells called B cell, while
limiting harmful immune reactions that can happen with some
similar treatments, Kali said.
* The drug developer, which focuses on next-generation
biologics, said KT501 is designed to target and modulate immune
cells that trigger autoimmune disorders, a category that
includes conditions such as lupus and rheumatoid arthritis.
* Sanofi already markets Kevzara, an approved rheumatoid
arthritis drug developed with Regeneron Pharmaceuticals ( REGN )
, and is also advancing new anti-inflammatory
candidates.
(Reporting by Siddhi Mahatole and Kunal Das in Bengaluru)