Sept 8 (Reuters) - Eli Lilly's ( LLY ) approved blood
cancer therapy Jaypirca helped delay progression of the disease
in previously untreated patients in a late-stage study,
advancing it as a potential first-line treatment option.
A further analysis measuring overall survival rates, another
key measure of efficacy, is planned next year. While data in the
trial for this secondary goal was not mature yet, it was
trending in favor of the treatment being superior to
chemoimmunotherapy, the U.S. drugmaker said on Monday.
Lilly is banking on therapies, such as Jaypirca and breast
cancer drug Verzenio, and other promising candidates to
strengthen its presence in the fast-growing but competitive
cancer treatments market.
In January, the drugmaker struck an up to $2.5 billion deal
to buy Scorpion Therapeutics' experimental oral therapy for
breast cancer and other advanced solid tumors.
Jaypirca was tested in patients with a type of chronic
lymphocytic leukemia, or small lymphocytic lymphoma (CLL/SLL),
characterized by an increased production of abnormal white blood
cells that have difficulty fighting infections.
In the study, 282 patients were randomly chosen to receive
Jaypirca or chemoimmunotherapy, Lilly said.
Earlier this year, Jaypirca was shown to be more effective
in a head-to-head study against AbbVie's ( ABBV ) top-selling
cancer drug Imbruvica. Both the treatments target a type of
protein called Bruton's tyrosine kinase.
Lilly said on Monday data from the studies would form the
basis to seek label expansions in earlier lines of therapy and
global regulatory submissions will begin later this year.
Jaypirca, which recorded $337 million in sales in 2024, has
accelerated approval for patients with CLL/SLL and mantle-cell
lymphoma, a rare type of blood cancer, who have had at least two
lines of therapy.
(Reporting by Mariam Sunny in Bengaluru; Editing by Sriraj
Kalluvila)