June 10 (Reuters) - Moderna ( MRNA ) said on Monday its
combination vaccine to protect against both COVID-19 and
influenza generated a stronger immune response in adults aged 50
and over when compared to separate shots against the viruses in
a late-stage trial.
In the study, the combination using messenger RNA technology
generated greater antibodies than currently marketed traditional
flu vaccines and Moderna's ( MRNA ) Spikevax mRNA COVID shot, the company
said.
The vaccine, called mRNA-1083, elicited a higher immune
response against two A strains and one B strain of the flu in
older adults when compared with widely used flu shots from GSK
and Sanofi, according to the company.
The U.S. Food and Drug Administration in March recommended
drugmakers target those three strains, called H1N1, H3N2, and
B/Victoria, when developing their seasonal flu vaccines for
2024.
The latest data was collected from two arms of a larger
study that involved around 8,000 people - one tested the
combination against GSK's Fluarix in adults aged 50 to 64 and
another against Sanofi's Fluzone HD in people 65 and older.
Fluzone is a high-dose vaccine for older people.
Moderna ( MRNA ) President Stephen Hoge said the drugmaker hopes to
launch the combination shot for the autumn respiratory disease
season in 2025. "If not 2025, then 2026," he said.
The Cambridge, Massachusetts-based company has been banking
on new vaccines to make up for vastly lower demand and sales for
its COVID shot.
If approved, the combination vaccine would be Moderna's ( MRNA )
third marketed product, having received FDA approval for its
respiratory syncytial virus (RSV) vaccine last month.
Moderna ( MRNA ) also said the combination was found to be safe and
tolerable in the latest study, and that rates of adverse side
effects were similar to those of the other vaccines used in the
trial.
The most common side effects were injection site pain,
fatigue, muscle aches and headache, Moderna ( MRNA ) said.
The company said it expects to release the full results from
the study at an upcoming medical conference.