BAGSVAERD, Denmark, March 8 (Reuters) - Novo Nordisk is

very comfortable it will be able to launch the pill version of

its experimental weight loss drug amycretin this decade, the

drugmaker's head of development told Reuters on Friday, a day

after it announced strong early trial data on it.

"I never commit to timelines but I would be very comfortable

to say at the very least within this decade," Martin Holst Lange

said in an interview.

Novo shares surged more than 8% to record highs

on Thursday when the company told investors a Phase I trial of

the pill version of amycretin showed participants lost 13.1% of

their weight after 12 weeks, a bigger reduction early on than

from Wegovy.

Shares in the drugmaker, which surpassed Tesla Inc ( TSLA )

in market value on Thursday, were down 0.9% on Friday but were

still set for a 7.1% gain this week.

Investors said the news shows the Danish company, originally

known as an insulin maker, has more in its pipeline beyond its

hugely successful Wegovy. Its shares have risen more than

three-fold since June 2021 when it launched Wegovy in the United

States.

It hopes both its new experimental obesity drugs cagrisema

and amycretin will have higher efficacy in terms of weight-loss

than Wegovy.

CARDIAC BENEFITS

After 12 weeks on amycretin in the trial, more than 80% of

the participants were still on the drug, Lange said, describing

it as an "impressive" retention rate which would suggest that

the doses were safe and patients were tolerating it well without

major side effects.

Lange added that it also "would be a likely scenario" that

the new drugs would have similar cardiac benefits as Wegovy.

Wegovy belongs to a class of drugs known as GLP-1 agonists,

originally designed to treat Type 2 diabetes, that have been

shown to regulate blood glucose levels and suppress appetite.

Following the success of Wegovy, companies are working on

other promising weight-loss therapies such as amycretin, which

in addition to binding to the same gut hormone as Wegovy --

GLP-1 -- also targets a hormone called amylin in the pancreas

that affects hunger.

Novo in August said a large study had shown Wegovy also had

a clear cardiovascular benefit, boosting the company's hopes of

moving beyond its image as a lifestyle drug.

Those results have led to a debate over whether the

long-term medical benefits of weight-loss drugs are enough to

reduce the overall burden on healthcare systems and the cost of

treating heart disease in overweight and obese people.

Novo's current plan is to advance the development of

amycretin in its oral and injectable form simultaneously, and it

gives a regulatory advantage to deliver safety data on both

versions at the same time, Lange said.

(Reporting by Maggie Fick and Jacob Gronholt-Pedersen, writing

by Stine Jacobsen and Louise Rasmussen, editing by Terje Solsvik

and Emelia Sithole-Matarise)