LONDON, July 16 (Reuters) - Swiss biotech company
Asceneuron said on Tuesday it had raised $100 million from
investors including the controlling shareholder of Wegovy maker
Novo Nordisk to fund clinical development of its Alzheimer's
disease drug.
The Series C round was led by Novo Holdings, the investment
arm of the Novo Nordisk Foundation, which will hold a board seat
on the Lausanne-based company.
Asceneuron's lead experimental drug ASN51 is from a new
class of drugs called O-GlcNAcase (OGA) inhibitors.
The company and Novo Holdings say they expect future trials
to uphold their assertion that ASN51 is superior to those from
the same class in development by rivals Biogen, Merck &
Co ( MRK ) and Eli Lilly ( LLY ).
OGA inhibitors prevent the aggregation of tau proteins in
the brain to slow Alzheimer's progression. They are pills and
could be a companion to another class of treatments that are
injections targeting the beta amyloid protein.
Asceneuron will use the funds for a phase 2 trial that will
begin later this year, CEO Barbara Angehrn Pavik said.
Naveed Siddiqi, senior partner at Novo Holdings, said that
for decades drugmakers had failed to develop effective
treatments for Alzheimer's despite the large number of people
suffering from it, deterring investors.
But the field has recently reached an inflection point, he
said, with breakthrough treatments that remove toxic proteins
from the brain spurring new interest. His view echoed those of
scientists and company executives interviewed by Reuters in
November.
A week ago Novo Holdings led a separate 90 million pound
($116.78 million) funding round for British biotech Myricx
Pharma to progress its experimental cancer drugs.
The wealth and influence of the Novo Nordisk Foundation is
growing rapidly on the back of soaring profits from Novo
Nordisk's weight-loss drug Wegovy and type 2 diabetes drug
Ozempic.
Novo Holdings' capital to invest is also burgeoning. Its CEO
Kasim Kutay told Reuters last year that its deal size in
healthcare will rise, particularly for its principal
investments, which is a separate part of the firm from the
venture investments group leading this month's deals.
($1 = 0.7707 pounds)