Dec 2 (Reuters) - Novocure ( NVCR ) said on Monday its
experimental therapy extended the lives of patients with a form
of advanced pancreatic cancer when combined with chemotherapy,
achieving the primary goal in a late-stage trial.
The therapy uses Tumor Treating Fields, or electric fields,
to kill cancer cells while sparing most nearby healthy cells,
using a portable device placed on the skin near the tumor.
In the study, TTFields therapy concomitant with chemotherapy
helped patients live for an average of 16.20 months, compared to
14.16 months in patients treated with chemotherapy alone,
Novocure ( NVCR ) said.
The treatment's safety was consistent with prior clinical
studies, the company said.
The therapy also helped improve survival rates over time,
according to Novocure ( NVCR ). The rate of overall survival, or the
length of time a patient lives from the start of treatment,
improved by 13% at 12 months and by 33% at 24 months, the
company said.
Novocure ( NVCR ) said it would present full data from the study at
an upcoming medical meeting and file for regulatory approval in
the United States, the EU, Japan and other markets.
The therapy is approved for use in some patients with a type
of lung cancer, a type of cancer that starts in the brain and
spinal cord as well as a rare cancer that grows in the membrane
lining the walls of the chest and lungs. Branded Optune Gio and
Optune Lua, it brought in about $509 million in revenue globally
in 2023.
The device had failed to improve survival rates in patients
with a type of ovarian cancer last year.
The latest study enrolled 571 patients with locally advanced
pancreatic adenocarcinoma, which cannot be removed surgically,
who received either TTFields therapy along with chemotherapy or
chemotherapy alone for at least 18 months.
Pancreatic cancer accounts for about 3% of all cancers in
the U.S. and about 7% of all cancer deaths, according to the
American Cancer Society.