COPENHAGEN, June 23 (Reuters) - Novo Nordisk's

popular obesity drug Wegovy helped women with a

common heart disease lose more weight than men who had the same

condition, an analysis of study data published in a medical

journal has shown.

The trials included 1,145 patients and were focused on a

condition known as heart failure with preserved ejection

fraction, or HFpEF, in which the muscles of the heart stiffen

and draw in less blood.

The data from the two trials, which tested the drug in

people with obesity-related heart failure along with HFpEF -

both with and without diabetes - was presented at the American

Diabetes Association's scientific meeting in Orlando, Florida,

on Sunday.

The drug produced similar improvements in HFpEF symptoms,

physical limitations and exercise function regardless of sex,

the data showed.

The prespecified analysis was published in the Journal of

the American College of Cardiology.

"We're seeing a benefit across males and females," said

Stephen Gough, Novo's chief medical officer, in an interview. He

added that trial data supported Wegovy's potential to deliver

clinical improvements in patients with heart failure.

Novo's trials were not designed to evaluate the treatment

effects of Wegovy, chemically known as semaglutide, by

biological sex.

About half of the patients enrolled in the trials were

females. They had a higher body mass index and worse symptoms of

heart failure, the analysis showed. Females were also less

likely to have abnormal heart rhythm or coronary artery disease,

compared to males.

The data showed that a 2.4 milligram dose of semaglutide

in patients with obesity-related HFpEF reduced body weight to a

greater extent in females. Females lost an average of 9.6% of

their weight, while males lost about 7.2% of body weight.

Heart failure benefits were found to be similar in males and

females, with both groups improving by an average of roughly 7.5

points on a 0-to-100-point scoring system.

Other studies have also shown a greater weight-loss response

in women than in men with semaglutide, for reasons that aren't

clear yet, according to the analysis.

The "key surprising finding" from the analysis was that

greater weight loss among females did not lead to similarly

greater improvements in heart failure symptoms, according to an

editorial published with the study.

More research was needed to identify the reasons for that

discrepancy, the researchers said.

Fewer serious adverse events were reported in patients who

received semaglutide, compared to those on a placebo, data

showed.

HFpEF accounts for about half of heart failure cases, with

symptoms including shortness of breath and swelling in the

extremities. The condition mostly affects overweight people and

is especially common among women, prior studies have shown.