NEW YORK, Sept 14 (Reuters) - Pfizer ( PFE ) is trying
to increase doctor awareness of and testing for a rare lung
cancer mutation to help boost use of its drug Braftovi, which
the pharmaceutical maker anticipates could grow to become the
standard of care.
The company presented three-year follow-up data from a Phase
2 study on Saturday looking at patients with BRAF V600E-mutant
metastatic non-small cell lung cancer who received Braftovi and
another Pfizer ( PFE ) drug, Mektovi, as a first treatment. The study
showed they had a median of over two-and-a-half years of
progression-free survival, a measure of how long treated
patients live before their cancer gets worse.
Chris Boshoff, Pfizer's ( PFE ) Chief Oncology Officer, said the new
data supports the use of the drug as standard of care for that
group and said it expects to get market penetration of up to 60%
in lung cancer patients with the mutation.
He said approximately 2% to 3% of lung cancers have the
mutation in question.
Standard of care for such patients is currently an
immunotherapy paired with chemotherapy, Boshoff said. The
combination of Braftovi and Mektovi has been approved for
patients with non-small cell lung cancer with the mutation since
last year.
"All patients with lung cancer should be tested for BRAF
mutations, and that could be done with a simple blood test," he
said. "It's a relatively easy test to identify these patients
who clearly would benefit significantly from having a targeted
therapy."
He said that fewer than 50% of lung cancer patients in the
U.S. are currently tested for the mutation. That number is even
lower globally.
"This is a space where Pfizer ( PFE ) is particularly well equipped,
not just in the US, but globally, to encourage testing and to
help educate physicians, pathologists, patients, and patient
advocate groups," Boshoff said. He said the test is covered by
insurance in the U.S.
Pfizer ( PFE ) sold close to $400 million of Braftovi and Mektovi
last year, but analysts are not currently forecasting
significant growth for the drugs, according to LSEG data.
One area where Boshoff said Braftovi could expand its market
is in colorectal cancer, where BRAF-mutated cancers make up 10%
of the cancers. Data from the company's late-stage study in
colorectal cancer is expected to be announced by the end of the
year, he said.