June 26 (Reuters) - Pfizer's ( PFE ) hemophilia therapy,
Hympavzi, met the main goal of a late-stage study in patients
with certain types of antibodies, the U.S. drugmaker said on
Thursday.
The data comes months after the company decided to stop
global development and sale of its hemophilia gene therapy,
Beqvez, citing soft demand from patients and their doctors.
Hympavzi is a weekly injection and is approved for patients
with hemophilia A without factor VIII antibodies or inhibitors,
or hemophilia B without factor IX inhibitors.
In the trial, 48 patients treated with Hympavzi saw a 93%
reduction in annualized bleeding rate over a year. It also met
all secondary goals, including showing a benefit in spontaneous
bleeds and joint bleeds.
The company's statement did not disclose the total number of
patients involved in the trial.
People with hemophilia have a defect in a gene that
regulates the production of proteins called clotting factors,
causing spontaneous and severe bleeding following injuries or
surgery.
Pfizer ( PFE ) said patients with inhibitors require treatments that
are less burdensome.
The hemophilia market has been dominated by factor
replacement therapies for decades.
Around 20% of people with hemophilia A and 3% of people with
hemophilia B are unable to continue factor replacement therapies
as they develop antibodies and the therapies fail to prevent or
stop bleeding episodes, Pfizer ( PFE ) said.
Other treatments include Sanofi's bimonthly gene
therapy Qfitlia for people with or without inhibitors, Novo
Nordisk's daily Alhemo, and gene therapies such as
CSL's Hemgenix and BioMarin Pharmaceutical's ( BMRN )
Roctavia.