LONDON, Jan 12 (Reuters) - Reigning champions Manchester United ( MANU ) will take on Leicester City in the fourth round of the FA Cup, while there are three all Premier League clashes following the draw on Sunday.

The fourth-round game will mark the return of Ruud van Nistelrooy, who was United's interim manager for four games earlier this season before being hired by Leicester, to Old Trafford.

Last season's runners-up Manchester City face an easier tie after being drawn against either League One (third tier) Leyton Orient or Championship side (second tier) Derby County.

Premier League leaders Liverpool will host Championship side Plymouth Argyle, while League Two (fourth tier) team Doncaster Rovers clash with Premier League team Crystal Palace.

Brighton & Hove Albion will play Chelsea, Everton take on Bournemouth and Aston Villa host Tottenham Hotspur in three tough clashes between Premier League teams.

Remaining third round matches take place on Monday and Tuesday. The fourth round will be played Feb. 7-10.