09:00 AM EDT, 07/23/2025 (MT Newswires) -- ANI Pharmaceuticals ( ANIP ) shares were down 7.3% in recent Wednesday premarket activity after the company said its study evaluating Iluvien in participants with diabetic macular edema did not meet its primary endpoint.

Otis Worldwide ( OTIS ) stock was down 6.5% after the company posted lower Q2 adjusted earnings from a year earlier.

Canadian National Railway ( CNI ) stock was down more than 3%, a day after the company reported lower Q2 revenue.