07:41 AM EST, 11/19/2025 (MT Newswires) -- Agios Pharmaceuticals ( AGIO ) shares were 34% lower pre-bell Wednesday after the company reported that its treatment candidate for sickle cell disease failed to achieve statistical significance in the primary endpoint of annualized rate of pain crises in a late-stage trial.

Qfin ( QFIN ) stock was down 13%, a day after the company reported lower fiscal Q3 adjusted earnings.

Aimei Health Technology ( AFJK ) shares were 10% lower, adding to losses from the previous session.