Nov 13 (Reuters) - Two workers were killed in an

explosion at a plant belonging to Swiss colour and aroma maker

Givaudan in Louisville, Kentucky, the company said on

Wednesday.

Several others were injured in the incident, which occurred

on Tuesday at Givaudan's Sense Colour factory in the

south-eastern U.S. state, the Swiss group said in an emailed

statement, without specifying how many.

In a statement dated Tuesday, Louisville Mayor Craig

Greenberg said firefighters had rescued many people from inside

and first-responders transported 12 patients with various

injuries ranging from minor to critical or life-threatening.

"We are in the early stages of investigating the cause of

this incident and are cooperating with first-responders and

supporting agencies," Givaudan said.

The local government said in a post on X that a

shelter-in-place order had been issued for those within a

one-mile radius of the site following to a "hazardous materials

incident".