10:55 AM EDT, 05/04/2025 (MT Newswires) -- CFRA, an independent research provider, has provided MT Newswires with the following research alert. Analysts at CFRA have summarized their opinion as follows:

We lower our target price to $321 from $331 based on our Net Present Value analysis. We narrow our 2025 LPS estimate to -$0.02 from -$1.62 as we expect to see improved profitability throughout the year. We adjust our 2026 EPS estimate to $2.77 from $3.08. Alnylam delivered strong Q1 2025 results, marking a significant milestone with GAAP operating profitability, in our view. The company reported Q4 total revenue of $543M, up 20% Y/Y, beating expectations, supported by 28% Y/Y growth in global net product revenues. The TTR franchise (Amvuttra+Onpattro) revenues of $359.5M continued their strong momentum, up 36% Y/Y. ALNY reiterated its financial guidance for 2025, with total net product revenues of $2.050B-$2.250B, which we find achievable. Alnylam also kept the total TTR net product revenues in the range of $1.6B-$1.73B. We expect total revenue to be above $2.8B in 2025, pointing to a robust 27% Y/Y growth, as we anticipate total TTR revenue (Amvuttra+Onpattro) continuing to grow above 35%.