U.S. stocks traded slightly lower midway through trading, with the Dow Jones index falling around 0.1% on Wednesday.

The Dow traded down 0.05% to 42,507.21 while the NASDAQ dipped 0.14% to 19,461.93. The S&P 500 also fell, dropping, 0.03% to 5,907.51.

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Leading and Lagging Sectors

Materials shares rose by 0.1% on Wednesday.

In trading on Wednesday, utilities shares tumbled by 1%.

Top Headline

U.S. initial jobless claims fell by 10,000 to 201,000 in the week ending Jan. 4, recording the lowest level in eleven months and versus market estimates of 218,000.

Equities Trading UP

Sana Biotechnology, Inc ( SANA ) shares shot up 193% to $4.8390 after the company on Tuesday announced clinical trial results from its type 1 diabetes study of islet cell transplantation without immunosuppression.

Shares of Silo Pharma, Inc. ( SILO ) got a boost, surging 141% to $2.6680 after the company announced it was awarded a US patent for its PTSD treatment titled ‘Pharmacological Prophylactics Against Stress-Induced Affective Disorders in Females.’

AngioDynamics, Inc. ( ANGO ) shares were also up, gaining 29% to $12.11 after the company reported better-than-expected second-quarter financial results and raised its FY25 adjusted EPS guidance.

Equities Trading DOWN

DatChat, Inc. ( DATS ) shares dropped 65% to $3.13 after the company announced the pricing of a $5.1 million registered direct offering priced at-the-market under Nasdaq rules.

Shares of Jasper Therapeutics, Inc ( JSPR ) were down 59% to $7.26. The company reported preliminary data from its BEACON Phase 1b/2a study.

XTI Aerospace, Inc. ( XTIA ) was down, falling 54% to $0.0529. XTI Aerospace ( XTIA ) priced $20 million offering of 363,636,364 shares of common stock at a price of $0.055 per share.

Commodities

In commodity news, oil traded down 1% to $73.50 while gold traded up 0.4% at $2,676.80.

Silver traded up 0.5% to $30.850 on Wednesday, while copper rose 1.2% to $4.2475.

Euro zone

European shares were lower today. The eurozone's STOXX 600 declined 0.54%, Germany's DAX 40 fell 0.34% and France's CAC 40 dipped 1.1%. Spain's IBEX 35 Index fell 0.61%, while London's FTSE 100 slipped 0.24%.

Asia Pacific Markets

Asian markets closed mostly lower on Wednesday, with Japan's Nikkei 225 falling 0.26%, China's Shanghai Composite Index gaining 0.02%, Hong Kong's Hang Seng Index declining 0.86% and India's BSE Sensex falling 0.07%.

Economics

U.S. private businesses added 122,000 workers to their payrolls in December down from 146,000 in November and versus expectations of 140,000.

U.S. initial jobless claims fell by 10,000 to 201,000 in the week ending Jan. 4, recording the lowest level in eleven months and versus market estimates of 218,000.

The Energy Information Administration said U.S. crude inventories declined by 0.959 million barrels last week, compared to market estimates of a 0.6 million barrel decline

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