09:14 AM EDT, 05/19/2026 (MT Newswires) -- The broad market exchange-traded fund SPDR S&P 500 ETF Trust ( SPY ) was down 0.4% and the actively traded Invesco QQQ Trust (QQQ) was 0.7% lower in Tuesday's premarket activity amid uncertainty surrounding US-Iran negotiations.

US stock futures were also lower, with S&P 500 Index futures down 0.4%, Dow Jones Industrial Average futures slipping 0.2%, and Nasdaq futures retreating 0.6% before the start of regular trading.

The pending home sales data for April will be released at 10 am ET.

In premarket activity, bitcoin was down by 0.2%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 0.3% lower, Ether ETF (EETH) retreated 0.7%, and Bitcoin & Ether Market Cap Weight ETF (BETH) declined by 0.02%.

Power Play:

Technology

The State Street Technology Select Sector SPDR ETF (XLK) retreated 1%, and the iShares US Technology ETF ( IYW ) was 0.6% lower, while the iShares Expanded Tech Sector ETF ( IGM ) was down 0.3%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF ( XSD ) declined by 3.4%, while the iShares Semiconductor ETF (SOXX) fell by 1.7%.

Agilysys ( AGYS ) shares were up more than 23% in premarket activity after the company overnight reported fiscal Q4 earnings and sales above market expectations.

Winners and Losers:

Healthcare

The State Street Health Care Select Sector SPDR ETF ( XLV ) retreated by 0.04%, the Vanguard Health Care Index Fund ( VHT ) was down 0.04%, while the iShares US Healthcare ETF ( IYH ) was inactive. The iShares Biotechnology ETF (IBB) was up 0.3%.

Relay Therapeutics ( RLAY ) stock was up more than 9% premarket after the company said that the early phase 2 data showed its experimental drug zovegalisib reduced lesion volume in patients with rare vascular anomalies linked to PIK3CA mutations.

Financial

The State Street Financial Select Sector SPDR ETF (XLF) retreated 0.1%. Direxion Daily Financial Bull 3X Shares (FAS) was down 0.01%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 0.1% higher.

XP (XP) shares were down 5.2% in premarket activity after the company overnight reported Q1 results that fell short of analyst expectations.

Consumer

The State Street Consumer Staples Select Sector SPDR ETF (XLP) was down 0.1%, and the Vanguard Consumer Staples Index Fund ETF Shares (VDC) was 0.4% lower. The iShares US Consumer Staples ETF ( IYK ) was flat. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) lost 0.7%. The VanEck Retail ETF ( RTH ) was inactive, while the State Street SPDR S&P Retail ETF (XRT) was 0.7% higher.

Amer Sports ( AS ) shares were up more than 3% pre-bell after the company reported Q1 adjusted earnings and revenue.

Industrial

The State Street Industrial Select Sector SPDR ETF ( XLI ) retreated 0.1%, while the Vanguard Industrials Index Fund ( VIS ) was 0.1% lower, and the iShares US Industrials ETF ( IYJ ) gained 0.2%.

Allegiant Travel ( ALGT ) stock was down more than 1% before the opening bell after the company said it is launching eight new nonstop routes beginning in fall 2026, expanding service across Florida leisure markets.

Energy

The iShares US Energy ETF ( IYE ) was 1.3%, while the State Street Energy Select Sector SPDR ETF ( XLE ) was up by 0.4%.

Equinor ( EQNR ) stock was up more than 1% before the opening bell after the company said it signed a 5-year agreement with Eneco to supply natural gas from the Norwegian continental shelf.

Commodities

Front-month US West Texas Intermediate crude oil retreated by 0.3% to $108.38 per barrel on the New York Mercantile Exchange. Natural gas was up 1.2% at $3.06 per 1 million British Thermal Units. The United States Oil Fund ( USO ) increased by 1.5%, while the United States Natural Gas Fund ( UNG ) was 1.2% higher.

Gold futures for May retreated by 0.5% to $4,534.30 an ounce on the Comex. Silver futures fell by 1.7% to $76.13 an ounce. SPDR Gold Shares ( GLD ) was down by 0.3%, and the iShares Silver Trust ( SLV ) declined by 1.5%.