09:01 AM EDT, 07/22/2026 (MT Newswires) -- The broad market exchange-traded fund SPDR S&P 500 ETF Trust ( SPY ) retreated 0.4%, and the actively traded Invesco QQQ Trust (QQQ) was down 1% in Wednesday's premarket activity, as investors awaited results from major technology companies.

US stock futures were also lower, with S&P 500 Index futures up 0.4%, Dow Jones Industrial Average futures slipping 0.2%, and Nasdaq futures retreating 0.9% before the start of regular trading.

Mortgage applications rose by 1.9% in the week ended July 17 despite an increase in 30-year fixed mortgage rates, according to Mortgage Bankers Association data released Wednesday.

The weekly petroleum stocks data will be released at 10:30 am ET.

In premarket action, bitcoin was down by 0.8%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 0.7% lower, Ether ETF (EETH) advanced 0.3%, and Bitcoin & Ether Market Cap Weight ETF (BETH) was flat.

Power Play:

Health Care

The State Street Health Care Select Sector SPDR ETF ( XLV ) advanced 0.1%, the Vanguard Health Care Index Fund ( VHT ) was up 1.3%, while the iShares US Healthcare ETF ( IYH ) slipped 0.6%. The iShares Biotechnology ETF (IBB) was 0.5% lower.

Dyne Therapeutics ( DYN ) stock was down more than 8% premarket after the company priced an upsized secondary public offering of 18.3 million shares at $20.50 each.

Winners and Losers:

Industrial

The State Street Industrial Select Sector SPDR ETF ( XLI ) retreated 0.7%, the Vanguard Industrials Index Fund ( VIS ) lost 0.01%, and the iShares US Industrials ETF ( IYJ ) was 0.5% higher.

GE Vernova ( GEV ) stock was down more than 1% before the opening bell after the company reported lower-than-expected Q2 earnings.

Consumer

The State Street Consumer Staples Select Sector SPDR ETF (XLP) was up 0.5%, the Vanguard Consumer Staples Index Fund ETF Shares (VDC) was flat, and the iShares US Consumer Staples ETF ( IYK ) was down 0.7%. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) lost 0.2%. The VanEck Retail ETF ( RTH ) was inactive, while the State Street SPDR S&P Retail ETF (XRT) was 0.6% higher.

Cal-Maine Foods ( CALM ) shares were down more than 4% pre-bell after the company swung to a fiscal Q4 loss.

Financial

The State Street Financial Select Sector SPDR ETF (XLF) advanced 0.04%. Direxion Daily Financial Bull 3X Shares (FAS) was down 0.1%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 0.1% lower.

Banco Santander (SAN) shares traded up 1% in early-hours activity after the company reported higher Q2 earnings and revenue.

Technology

The State Street Technology Select Sector SPDR ETF (XLK) retreated 1.3%, the iShares US Technology ETF ( IYW ) was 0.2% lower, and the iShares Expanded Tech Sector ETF ( IGM ) was up 0.8%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF ( XSD ) fell by 1.8%, while the iShares Semiconductor ETF (SOXX) was down 2.8%.

Nvidia ( NVDA ) shares were down more than 1% in premarket activity after gaining nearly 2% at the prior close. Chief Executive Jensen Huang is expected to meet Samsung Electronics Chairman Jay Lee, SK Group Chairman Chey Tae-won and Naver founder Lee Hae-jin in the US this week for an artificial intelligence roundtable, according to news reports.

Energy

The iShares US Energy ETF ( IYE ) was flat, while the State Street Energy Select Sector SPDR ETF ( XLE ) was up by 1.1%.

Shell (SHEL) stock was up more than 1% before market open following a 1.2% gain in the previous session. The company resumed operations at a 200,000-barrel-per-day crude oil unit at its Pernis oil refinery in the Netherlands on Monday following a brief disruption, Reuters reported Tuesday.

Commodities

Front-month US West Texas Intermediate crude oil advanced by 3.4% to $87.24 per barrel on the New York Mercantile Exchange. Natural gas was up by 1.7% to $2.91 per 1 million British Thermal Units. The United States Oil Fund ( USO ) was up 2.8%, while the United States Natural Gas Fund ( UNG ) was 1.1% higher.

Gold futures for July advanced 1.3% to $4,128.70 an ounce on the Comex. Silver futures were up 0.9% to $59.64 an ounce. SPDR Gold Shares ( GLD ) increased 1.1%, and the iShares Silver Trust ( SLV ) was 1.4% higher.