08:57 AM EST, 11/19/2025 (MT Newswires) -- Health care stocks were advancing premarket Wednesday, with the Health Care Select Sector SPDR Fund (XLV) 0.2% higher and the iShares Biotechnology ETF (IBB) up 0.3%.

Agios Pharmaceuticals ( AGIO ) shares were down more than 49% after the company said its potential sickle cell disease treatment mitapivat failed to meet one of two primary endpoints in a 52-week phase 3 clinical trial.