09:14 AM EDT, 08/12/2026 (MT Newswires) -- Healthcare stocks were leaning lower premarket Wednesday, with the State Street Health Care Select Sector SPDR ETF ( XLV ) declining by 0.4% and the iShares Biotechnology ETF (IBB) down 0.1%.

Definium Therapeutics ( DFTX ) shares were up more than 16% after the company said its phase 3 Voyage study of DT120 lysergide orally disintegrating tablets in adults with generalized anxiety disorder met its primary endpoint.

Arbutus Biopharma ( ABUS ) stock was down more than 3% after the company reported that it swung to a Q2 loss as revenue fell during the period.

Natera's ( NTRA ) Latitude tissue-free assay for molecular residual disease detection will be used by Kupando Therapeutics in a phase 1 clinical trial of its lead immunotherapy candidate, KUP-101, Natera ( NTRA ) said. Shares of Natera ( NTRA ) were up more than 1% pre-bell.