02:33 PM EST, 12/04/2024 (MT Newswires) -- Relmada Therapeutics ( RLMD ) said Wednesday that an Independent Data Monitoring Committee has determined that a late-stage study of REL-1017 as an adjunctive treatment for major depressive disorder is "futile."

The committee said the trial is unlikely to meet the primary efficacy endpoint with statistical significance.

Shares slumped nearly 77%, with intraday trading volume at over 15.1 million compared with a daily average of about 194,000.

PSQ Holdings ( PSQH ) said Wednesday that it has agreed to sell 7.8 million class A shares at $4.63 per share in a registered direct offering for $36.2 million.

Shares sank nearly 33% as intraday trading volume jumped to over 24.8 million from a daily average of about 2.9 million.

MarketAxess Holdings ( MKTX ) said Wednesday its average daily volume stood at $44.95 billion in November, up 56% from a year earlier but down 3% compared with October.

Total rates ADV was $30.7 billion in November, up 112% from a year ago but down 2% from the prior month.

Shares retreated 7% as intraday trading volume climbed to more than 621,000 compared with a daily average of roughly 383,000.

Price: 0.64, Change: -2.13, Percent Change: -76.82