02:17 PM EST, 11/19/2025 (MT Newswires) -- Agios Pharmaceuticals' ( AGIO ) shares sank 48% amid heavy trading after the firm reported Wednesday that its potential sickle cell disease treatment, mitapivat, failed to meet one of two primary endpoints in a Phase 3 clinical trial over 52 weeks.

More than 13.2 million shares of the company traded intraday compared with a daily average of about 655,000.

Strategy (MSTR) shares slumped 11% amid a 4.4% decline in Bitcoin to $89,829.11 after midday.

Over 18.1 million shares of Microstrategy, whose shares tend to mimic the cryptocurrency, traded intraday compared with a daily average of roughly 12.1 million.

EZGO Technologies ( EZGO ) announced a 1-for-25 reverse share split on Wednesday to maintain its Nasdaq listing by increasing the market price of its ordinary shares.

Shares dropped 36%, with intraday trading volume rising to over 7.4 million from the stock's daily average of roughly 13.4 million.

Price: 23.57, Change: -21.92, Percent Change: -48.18