April 22 (Reuters) - Wall Street futures rose on Wednesday after U.S. President Donald Trump extended the ceasefire with Iran indefinitely, even as uncertainty remained over whether Tehran and U.S. ally Israel would honor the truce.

At 4:37 a.m. ET, Dow e-minis rose 171 points, or 0.35%, S&P 500 E-minis gained 31 points, or 0.44%, and Nasdaq 100 E-minis added 155.5 points, or 0.58%.

The bullish sentiment points to a market desperate for good news, with investors clinging to the view that peak uncertainty has passed, despite risks that inflation could flare up.

The S&P 500 and the Nasdaq Composite hit record highs in recent days even though oil prices remain near the $100-a-barrel mark.

"The peace process is looking wobbly again as some of the difficult realities of the war come to the fore," said Kyle Rodda, senior financial market analyst at Capital.com.

"The risk is (that) Iran's domestic political dynamics and strategic tensions between the U.S. and Iran -- not to mention Israel -- maintain an inertia towards escalation."

Trump said in a statement on social media the U.S. had agreed to a ‌request by Pakistani mediators "to hold our Attack on the Country of Iran until such time as their leaders and representatives can come up with a unified proposal ... and discussions are concluded, one way or the other."

Investors were also set to scrutinize a fresh batch of earnings reports, with planemaker Boeing and medical device maker Boston Scientific among the companies reporting results before market open.

Boeing shares rose 2.6% in premarket trading, while Boston Scientific was up 1.2%.

EV giant Tesla, chipmaker Texas Instruments and Southwest Airlines will report after market close.

Earnings so far have reassured investors about the health of the U.S. consumer, the growth engine of the economy. S&P 500 EPS estimates for 2026 and 2027 have risen by 4% since late January, according to data from Goldman Sachs.

Adobe was 2.8% higher after it unveiled a share repurchase program worth up to $25 billion.

Crypto-related stocks gained, with Coinbase Global and Strategy up 4% and 5.6%, respectively.

(Reporting by Niket Nishant in Bengaluru; Editing by Devika Syamnath)