April 10 (Reuters) - Wall Street's main indexes opened

lower on Wednesday after a hotter-than-anticipated inflation

reading dampened hopes of the Federal Reserve kicking off the

monetary easing cycle in June.

The Dow Jones Industrial Average fell 221.39 points,

or 0.57%, at the open to 38,662.28.

The S&P 500 opened lower by 42.03 points, or 0.81%,

at 5,167.88, while the Nasdaq Composite dropped 202.63

points, or 1.24%, to 16,104.01 at the opening bell.