March 26 (Reuters) - Wall Street's main indexes opened

lower open on Thursday following gains in the previous session,

as caution prevailed about developments in the Middle East while

weighing the prospects for de-escalation in the conflict.

The Dow Jones Industrial Average fell 84.8 points, or

0.18%, at the open to 46,344.64. The S&P 500 fell 36.0

points, or 0.55%, to 6,555.86​, while the Nasdaq Composite

dropped 236.7 points, or 1.08%, to 21,693.175.

(Reporting by Purvi Agarwal in Bengaluru)