(Recasts with preliminary close of trading)

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Healthcare sector slides; Pfizer's ( PFE ) forecast disappoints

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US job growth rebounded in November; unemployment rate at

4.6%

By Abigail Summerville and Johann M Cherian

Dec 16 (Reuters) - Wall Street's main indexes pared some

losses on Tuesday afternoon with the Nasdaq closing up, and the

S&P 500 and the Dow closing lower, impacted by declines in

healthcare and energy stocks. Investors evaluated delayed

economic data to gauge the Federal Reserve's monetary policy

outlook for next year.

A Labor Department report showed nonfarm payrolls increased by

64,000 jobs in November following a decline in October because

of government spending cuts. But the unemployment rate rose to

4.6% in November against the backdrop of economic uncertainty

stemming from President Donald Trump's aggressive trade policy.

A separate report on Tuesday showed retail sales were flat

in October, just below an estimate of economists polled by

Reuters calling for a rise of 0.1%. Analysts flagged the

likelihood of the figures being distorted by slow data

collection due to a recent government shutdown.

"This is all fairly old news at this point. Most data points

are being viewed in the lens of what they are going to do to the

Fed, and the data you got today isn't likely to move the

needle," said Mark Hackett, chief market strategist at

Nationwide.

After Tuesday's data, investors are pricing in interest rate

cuts of at least 58 basis points next year - more than double

the 25 bps signaled by the Fed last week.

Trump is set to interview Fed Governor Christopher Waller on

Wednesday for the Federal Reserve chair position, the Wall

Street Journal reported Tuesday afternoon.

According to preliminary data, the S&P 500 lost 16.42

points, or 0.24%, to end at 6,800.09 points, while the Nasdaq

Composite gained 54.05 points, or 0.23%, to 23,111.46.

The Dow Jones Industrial Average fell 302.67 points, or

0.63%, to 48,113.89.

Crude prices hit their lowest level since 2021.

"The crude move today is the one that stands out. Everything

else seems like lethargy among investors and just a modest

technical move to the sidelines," Hackett said.

In health stocks, Pfizer ( PFE ) fell after the drugmaker

forecast a challenging 2026 due to weaker sales of COVID-19

products and squeezed margins. Humana slipped after the

health insurer announced undefined leadership changes.

The S&P 500 and the Nasdaq hovered near their three-week

lows as persistent uncertainty over rate cuts and concerns about

lofty tech valuations continued to weigh on market sentiment.

Among other stocks, B. Riley jumped after the

investment bank reported a profit for the second quarter,

compared with a year-ago loss in an overdue quarterly filing.

Comcast ( CMCSA ) rose after CNBC financial journalist David

Faber speculated about potential involvement by an activist

investor.

Separately, a Reuters report said Nasdaq submitted

paperwork with the U.S. Securities and Exchange Commission to

roll out round-the-clock trading of stocks, months after the New

York Stock Exchange and Cboe Global Markets announced similar

plans.