12:16 PM EDT, 10/07/2025 (MT Newswires) -- The European stock markets closed little changed in Tuesday trading as the Stoxx Europe 600 declined 0.15%, the Swiss Market Index was off 0.24%, while the UK's FTSE 100, Germany's DAX, and France's CAC were little changed.

In Germany, price-adjusted new orders in manufacturing declined 0.8% in August from July, according to preliminary data from the Federal Statistical Office. Excluding large-scale orders, new orders dropped 3.3% from July.

In the UK, the average UK house price declined by 794 British pounds ($1,067.30) to 298,184 pounds in September compared with August, according to the Halifax Price Index, which also showed that home prices are up 1.3% from a year earlier. "This slight monthly dip in house prices reflects a housing market that has remained broadly stable," Amanda Bryden, Halifax's head of mortgages, said in a statement.

And in corporate news, Novo Nordisk on Monday lost its appeal against the US Government's Medicare Drug Price Negotiation Program that gives it the power to reduce prices of prescription drugs. The US Court of Appeals for the Third Circuit upheld a lower court ruling rejecting the drugmaker's challenge to the program and the Centers for Medicare and Medicaid Services' selection of six of the company's insulin products as a single "negotiation-eligible drug."

"We are disappointed with the decision of the US Court of Appeals for the Third Circuit and are assessing our options to appeal this ruling," a Novo Nordisk spokesperson told MT Newswires. "Novo Nordisk remains opposed to government price setting through the Inflation Reduction Act and has significant concerns about the law and with how CMS implemented the statute," the spokesperson said.

Shares of the Danish pharmaceutical giant fell close to 3% in Copenhagen.

Automaker Stellantis, along with Toyota and Ford, faces potential production disruptions after a recent fire at Novelis' Oswego aluminum plant in New York, The Wall Street Journal reported Monday, citing filings and sources familiar with the matter. The report said Ford is the plant's biggest user, with sources saying the company is likely to flag the fire's potential impacts to the production of its F-150 pickup when it issues its quarterly financial report later this month.

Toyota, Ford, and Stellantis did not immediately respond to MT Newswires' requests for comments.

Shares of the European automaker gained 1.2% on the CAC in Paris.

AstraZeneca said Tuesday its phase 3 trial of baxdrostat in patients with treatment-resistant hypertension met its primary endpoint. The investigational drug showed a statistically significant and clinically meaningful reduction in ambulatory 24-hour average systolic blood pressure at 12 weeks, compared with placebo, according to AstraZeneca.

Shares of the British pharmaceutical company gained 0.42% on the FTSE 100 in London.

The "politicization" of critical minerals is complicating mining deals, the Financial Times reported Monday, citing BHP Group Chief Development Officer Catherine Raw.

"The voice of the stakeholder, specifically the government and the regulator, is becoming louder and therefore the nature of any deal is going to become more complicated," Raw reportedly told the publication in an interview.

BHP didn't immediately respond to MT Newswires' request for comment.

Shares of the British mining company were off 0.2% in London.

Shell is working with the Indonesian government and other stakeholders to restock gasoline at its fuel stations as quickly as possible, Bloomberg reported Tuesday, citing a company spokesperson. The company's retail stations in Indonesia are experiencing gasoline shortages for the second time in less than two months, due to ongoing import restrictions, the report said.

Shell did not respond to MT Newswires' request for comment.

Shares of the oil and gas giant rose 1.5% on the FTSE 100.