10:54 AM EDT, 08/27/2025 (MT Newswires) -- European equities traded in the US as American depositary receipts were trending lower late Wednesday morning, declining 0.69% to 1,518.75 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by accommodations booking site trivago (TRVG) and biopharmaceutical company Cellectis ( CLLS ) , which advanced 5% and 4.1% respectively. They were followed by medical device maker EDAP TMS ( EDAP ) and semiconductor company Sequans Communications ( SQNS ) , which increased 2.6% and 2.5% respectively.

The decliners from continental Europe were led by financial services companies Banco Bilbao Vizcaya Argentaria ( BBVA ) and Banco Santander (SAN), which fell 2.6% and 2.1% respectively. They were followed by biotech firms BioNTech (BNTX) and Evaxion ( EVAX ) , which dropped 2% and 1.9% respectively.

From the UK and Ireland, the gainers were led by biopharmaceutical company Biodexa Pharmaceuticals ( BDRX ) and biotech firm Trinity Biotech ( TRIB ) , which rose 3.9% and 3.2% respectively. They were followed by software company Endava ( DAVA ) and biopharmaceutical company Mereo BioPharma Group ( MREO ) , which were up 2.5% and 1.7% respectively.

The decliners from the UK and Ireland were led by biopharmaceutical company Akari Therapeutics ( AKTX ) and insurance company Prudential (PUK), which lost 5.6% and 2.5% respectively. They were followed by financial services companies Barclays ( BCS ) and HSBC ( HSBC ) , which were down 2% and 1.7% respectively.