11:10 AM EDT, 10/22/2025 (MT Newswires) -- European equities traded in the US as American depositary receipts were tracking higher late Wednesday morning, rising 0.62% to 1,588.10 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by biopharmaceutical company Genfit ( GNFT ) and biopharmaceutical company Grifols ( GRFS ) , which rose 2.6% and 1.9% respectively. They were followed by health technology company Royal Philips (PHG) and petroleum refiner Equinor ( EQNR ) , which were up 2.6% and 1.7% respectively.

The decliners from continental Europe were led by biotech firm Evaxion ( EVAX ) and semiconductor company Sequans Communications ( SQNS ) , which fell 9.5% and 5.2% respectively. They were followed by pharmaceutical company Novo Nordisk ( NVO ) and internet browser company Opera (OPRA), which dropped 2.6% and 3.2% respectively.

From the UK and Ireland, the gainers were led by biopharmaceutical company Adaptimmune Therapeutics ( ADAP ) and lender Barclays ( BCS ) , which advanced 59% and 5.4% respectively. They were followed by hospitality company InterContinental Hotels Group ( IHG ) and communications firm WPP ( WPP ) , which increased 2.7% and 2.5% respectively.

The decliners from the UK and Ireland were led by biopharmaceutical company Biodexa Pharmaceuticals ( BDRX ) and biotech company Trinity Biotech ( TRIB ) , which lost 12.2% and 6.3% respectively. They were followed by biopharmaceutical companies NuCana ( NCNA ) and Mereo BioPharma Group ( MREO ) , which were down 4.7% and 3.1% respectively.