NEW YORK/LONDON, Feb 19 (Reuters) - An index of global

shares was lower on Wednesday, pressured by a retreat in Wall

Street and European stocks, as U.S. President Donald Trump's

latest tariff threats on auto, semiconductor and pharmaceutical

imports injected a sense of caution into the markets.

Since his inauguration four weeks ago, Trump has imposed a

10% tariff on all imports from China, on top of existing levies.

He has also announced, and delayed for a month, 25% tariffs on

goods from Mexico and non-energy imports from Canada.

Trump told reporters on Tuesday that sector-wide tariffs on

pharmaceuticals and semiconductor chips would start at "25% or

higher", rising substantially over the course of a year. He

intends to impose similar tariffs on autos as soon as April 2.

The Dow Jones Industrial Average fell 0.33% to

44,405.85, the S&P 500 fell 0.25% to 6,114.14 and the

Nasdaq Composite fell 0.45% to 19,950.91.

Stocks in Europe extended losses as a rally in drugmakers

and miners faded, adding to pressure from a broad-based decline

in UK equities after data showed a pickup in British inflation.

The STOXX 600 was last down 0.9%. Both the S&P 500 and

STOXX 600 indexes had finished at record highs on Tuesday.

MSCI's gauge of stocks across the globe

fell 0.41% to 884.10.

"In general the bias for markets remains upwards but if you

look shorter term over the last few days, it's more mixed

because the market tends to trade around the latest indications

of the Trump administration," said Julian McManus, portfolio

manager at Janus Henderson Investors.

"That tends to be unsettling and markets tend to trade off

whenever they hear the word tariff because they think it means

either risk for a particular country or they think inflation."