* US stocks down, with Nasdaq leading losses

* Investors wary as Iran reviews US proposal

* Investors worry about energy price shocks

(Updates to late morning)

By Caroline Valetkevitch and Marc Jones

NEW YORK/LONDON, March 26 (Reuters) - Major stock

indexes eased on Thursday as Brent oil futures rose above $105 a

barrel, with Iran's denial of any talks with the U.S. dimming

hopes of a quick resolution to the nearly one-month-long Middle

East war.

Global debt markets also sold off, pushing yields higher,

while safe-haven buying boosted the U.S. dollar.

Prospects of a prolonged war in the Middle East fanned

worries about energy supply disruptions. Oil and European

natural gas rose, with Brent futures up $4.77 at $106.99

a barrel and U.S. crude futures up at $93.64.

U.S. President ​Donald Trump warned Iran on Thursday to "get

serious" about a deal to end nearly four weeks of fighting.

Iran's Foreign Minister Abbas Araqchi had earlier said

Tehran was reviewing the U.S. proposal but that there were no

talks on winding down the war. Iran on Thursday launched

multiple waves of missiles at Israel.

The war, triggered by U.S.-Israeli strikes on Iran in late

February, has rattled global markets and effectively shut the

Strait of Hormuz, a conduit for a fifth of global oil and

liquefied natural gas flows.

Stocks fell "as oil prices resumed their upward climb", said

Peter Cardillo, chief market economist at Spartan Capital

Securities in New York.

"Unfortunately, we're in a market that's being driven by oil

prices. The rhetoric back and forth is continuing, and until

talks begin, the market is going to be subject to the price of

oil," he said.

The Dow Jones Industrial Average fell 75.50 points,

or 0.19%, to 46,342.69, the S&P 500 fell 43.59 points, or

0.68%, to 6,547.14 and the Nasdaq Composite fell 216.95

points, or 1.02%, to 21,705.16.

MSCI's gauge of stocks across the globe

dropped 6.75 points, or 0.68%, to 988.71. The pan-European STOXX

600 index fell 0.64%.

Japan's Nikkei ended down 0.3%, while worries over

rising energy costs hammered South Korea's KOSPI, which

slumped 3.2%. Hong Kong's Hang Seng fell 1.9% and China's

blue chips dropped 1.3%.

The Philippines held an unscheduled central bank meeting due

to the turmoil, while Germany's central bank head said an ECB

rate hike next month was "an option".

Fears of a 2022-style inflation shock have seen traders

fully price out any chance of a Federal Reserve rate cut this

year, further supporting the dollar.

Germany's two-year bond yield, sensitive to

European Central Bank rate expectations, rose after falling on

Wednesday. Bond yields move inversely to prices.

Worries about persistent inflation also drove U.S. Treasury

yields higher. The benchmark U.S. 10-year Treasury yield

was last up 4.2 basis points at 4.37%. The two-year

note's yield was last up 5.4 bps at 3.934%.

Earlier, the yield on Japan's two-year government bond

hit its highest level in 30 years at 1.33%, as

traders cemented bets on another Bank of Japan rate hike as

early as next month.

In currencies, the U.S. dollar rose against most major

currencies, reviving its safe-haven appeal.

The dollar index, which measures the greenback

against a basket of currencies including the yen and the euro,

rose 0.1% to 99.75, with the euro down 0.13% at $1.1544.

Against the Japanese yen, the dollar strengthened 0.04%

to 159.53.

Gold retreated as the dollar rose. Spot gold was down

0.89% at $4,465.06 an ounce.