July 18 (Reuters) - Bristol Myers Squibb ( BMY ) said on
Friday its blockbuster drug Reblozyl in combination with another
therapy failed to meet the main goal of a late-stage trial to
treat anemia due to a rare bone marrow cancer.
The study did not achieve statistically significant results
in helping patients become free from red blood cell transfusions
for any 12-week period during the first 24 weeks of treatment.
However, more patients receiving Reblozyl saw a reduction in
the number of transfusions needed and an increase in hemoglobin
levels, a key measure of anemia, the company said. The side
effects seen in the trial were similar to those previously
reported for Reblozyl.
Reblozyl is already approved for certain types of anemia
related to other blood disorders, including myelodysplastic
syndromes and beta thalassemia. Bristol Myers recorded $1.77
billion in global sales of Reblozyl in 2024.
In the late-stage trial, the drug was being tested to
treat anemia in myelofibrosis patients with a Janus kinase
inhibitor drug, a class of medicines that works by slowing down
the immune system.
Myelofibrosis is a type of cancer, in which the bone
marrow becomes scarred and doesn't produce enough healthy blood
cells.