(For a Reuters live blog on U.S., UK and European stock

markets, click LIVE/ or type LIVE/ in a news window)

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July JOLTS report awaited at 10:00 a.m. ET

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Nvidia drops after report of subpoena from US DoJ

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Dollar Tree ( DLTR ) dives after cutting annual forecasts

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Futures off: Dow 0.18%, S&P 500 0.42%, Nasdaq 0.75%

(Updated at 08:34 a.m. ET/ 1234 GMT)

By Johann M Cherian and Purvi Agarwal

Sept 4 (Reuters) - Wall Street's main indexes were set

to open lower on Wednesday, as fresh worries over the health of

the U.S. economy kept investors on the sidelines in the run-up

to labor data.

In the previous session, the indexes had logged their

biggest one-day loss since early August as investors dumped

technology-related stocks in a dour start to September.

Since 1928, the benchmark S&P 500 has recorded losses of

about 1.2% on average in the historically weak month for U.S.

equities.

"You've got a market that is as nervous as it often gets in

September, but we're not looking at back-to-back large down

days," said Art Hogan, chief market strategist at B Riley

Wealth.

The risk-off mood was exacerbated by data that showed

manufacturing activity shrank, nearly a month after signs of

softening labor demand sparked a global market rout.

"The manufacturing impact on the U.S. economy often gets

overstated. It's more important to focus on things like the

labor market and investors will lean a lot more into those data

points," Hogan said.

Traders now await July's Job Openings and Labor Turnover

Survey at 10 a.m. ET and non-farm payrolls report on Friday,

which could offer clues on the size of the Federal Reserve's

expected interest-rate cut in September.

Markets expect a 59% chance of a 25 basis points cut,

according to CME Group's FedWatch Tool, while that of a 50 bps

cut has increased to 41% from around 31% a day earlier.

Data on July factory orders and the Fed's survey, known as

the "Beige Book", are also expected on Wednesday.

At 08:34 a.m. ET, Dow E-minis were down 72 points,

or 0.18%, S&P 500 E-minis were down 23.25 points, or

0.42% and Nasdaq 100 E-minis were down 143.25 points, or

0.75%.

Chip stocks fell in the previous session, with the

Philadelphia SE Semiconductor index falling 7.8% to its

steepest one-day drop since the COVID-19 pandemic.

Nvidia fell 2% in premarket trading after a report

said the U.S. Department of Justice sent a subpoena to the AI

chip firm as it deepens its probe into the company's antitrust

practices.

A 10% slump in the previous session had wiped off a record

$279 billion from Nvidia's ( NVDA ) market capitalization - the biggest

ever single-day decline in market value for a U.S. company.

Other growth stocks such as Tesla fell 1%, while

Apple ( AAPL ) and Microsoft ( MSFT ) slipped 0.8% each.

Among others, Advanced Micro Devices ( AMD ) rose 1.7% after

the chipmaker appointed former Nvidia executive Keith

Strier as senior vice president of global AI markets.

Zscaler ( ZS ) forecast fiscal 2025 revenue and profit below

estimates, sending the cybersecurity company's shares down

17.4%.

Dollar Tree ( DLTR ) slumped 10.4% after the discount store

operator trimmed its annual sales and profit forecasts, while -

Skippy peanut butter maker Hormel Foods ( HRL ) slid 6.6% after

it lowered its annual sales view.

Intel ( INTC ) slipped 2.8%. A report showed the chipmaker's

contract manufacturing business suffered a setback after tests

with chipmaker Broadcom ( AVGO ) failed.