(For a Reuters live blog on U.S., UK and European stock

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Indexes down: Dow 1.04%, S&P 500 1.13%, Nasdaq 1.81%

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Datadog ( DDOG ) gains after annual profit, revenue forecast raise

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DoorDash ( DASH ) slides after quarterly revenue miss

(Updates prices)

By Twesha Dikshit and Purvi Agarwal

Nov 6 (Reuters) - Wall Street's main indexes fell to

near two-week lows on Thursday, as technology stocks came under

fresh selling pressure, while U.S. tariff concerns and

uncertainty around the health of the economy kept investors on

edge.

Most tech stocks declined as worries over stretched

valuations resurfaced, after a brief respite on Wednesday.

Warnings of a market pullback from Wall Street executives on

Tuesday had prompted a sharp equity sell-off led by AI-linked

stocks.

Heavyweights Microsoft ( MSFT ) and Nvidia ( NVDA ) lost

1.8% and 3%, respectively, weighing on the information

technology sector. The broader semiconductor index

was down 2.4%.

Qualcomm ( QCOM ) dipped 4.9% after the chip designer warned

of a possible loss of business next year from its key customer,

Samsung, but issued an upbeat forecast.

DoorDash ( DASH ) slumped 16.5% to the bottom of the S&P 500

after the delivery firm reported third-quarter profit below Wall

Street expectations, while Tapestry lost 10.7% after

forecasting holiday-quarter earnings below expectations.

The stocks weighed on the consumer discretionary sector

, which fell 2.7%.

Tesla fell 4.5%, ahead of a shareholders' vote,

where they will decide on CEO Elon Musk's heavy compensation

among other proposals.

"We have uncertainty from the Fed decision next month, on

where the tariffs are going, with the government shutdown... the

markets are a little bit cautious right now," said Dennis Dick,

chief strategist at Stock Trader Network.

"It's been an excellent couple of months for the market and

a little bit of a corrective phase here is warranted."

At 12:02 p.m. ET, the Dow Jones Industrial Average

fell 490.10 points, or 1.04%, to 46,820.90, the S&P 500

lost 76.72 points, or 1.13%, to 6,719.71 and the Nasdaq

Composite lost 424.46 points, or 1.81%, to 23,075.34.

The longest U.S. government shutdown in history has led to

investors and the Federal Reserve to rely on mixed private

sector indicators ahead of December's monetary policy meeting.

Global outplacement company Challenger, Gray & Christmas said

on Thursday layoffs announced by U.S. employers surged in

October, marking the highest level for the month in 22 years,

while data from Revelio Labs showed the economy shed jobs last

month.

An estimate by the Chicago Fed showed U.S. jobless rate

likely edged up in October to the highest in four years.

The datasets were in contrast to Wednesday's strong ADP

report, spurring uncertainty over the health of the U.S. labor

market.

Chicago Fed President Austan Goolsbee also reiterated his

cautious stance on further rate cuts in the absence of official

data. Comments from other Fed officials will also be parsed

through the day.

Investors assessed a bag of mixed corporate earnings.

Datadog ( DDOG ) topped the S&P 500 with a 22.2% surge after the

cloud security firm raised its annual profit and revenue

forecasts.

Robinhood dropped 8.9% after the online brokerage

raised its forecast for fiscal-year operating expenses.

Drugmakers Eli Lilly and Novo Nordisk unveiled a deal to

slash the prices of popular GLP-1 weight-loss drugs for the

government's Medicare and Medicaid programs, and for cash

payers.

Eli Lilly ( LLY ) extended gains to trade 1.8% higher, while

U.S.-listed shares of Novo Nordisk were flat in choppy

trading.

Among others, DraftKings ( DKNG ) was up 8.9% after a

Bloomberg News report that Disney ( DIS ) signed the company as

ESPN's ( DIS ) new sports-betting partner.

Declining issues outnumbered advancers by a 2.01-to-1 ratio

on the NYSE and by a 2.77-to-1 ratio on the Nasdaq.

The S&P 500 posted 16 new 52-week highs and 20 new lows while

the Nasdaq Composite recorded 70 new highs and 190 new lows.