(Reuters) - Wall Street's main indexes opened lower on Tuesday, hurt by sharp losses in health insurers and Tesla, while investors awaited comments from Federal Reserve officials and more economic data.

The Dow Jones Industrial Average fell 310.58 points, or 0.78%, at the open to 39,256.27.

The S&P 500 opened lower by 39.48 points, or 0.75%, at 5,204.29, while the Nasdaq Composite dropped 197.60 points, or 1.21%, to 16,199.24 at the opening bell.

(Reporting by Shashwat Chauhan in Bengaluru; Editing by Arun Koyyur)