US stocks edged lower at open on Wednesday, pressured by FedEx's warning on full-year profit, while investors waited for the Federal Reserve's decision on interest rates.

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The Dow Jones Industrial Average fell 35.41 points, or 0.13%, at the open to 27,075.39.

The S&P 500 opened lower by 4.20 points, or 0.14%, at 3,001.50. The Nasdaq Composite dropped 11.39 points, or 0.14%, to 8,174.62 at the opening bell.