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Vanda Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of therapies to address high unmet medical needs worldwide.

The company's marketed products include HETLIOZ to treat non-24-hour sleep-wake disorders; and Fanapt oral tablets for the treatment of schizophrenia.

Its pipeline products include HETLIOZ (tasimelteon) to treat jet lag disorder, insomnia, delayed sleep phase disorder, sleep disturbances in autism spectrum disorder, and pediatric Non-24; Fanapt (iloperidone) for the treatment of bipolar I disorder and Parkinson's disease psychosis, as well as a long acting injectable (LAI) formulation to treat schizophrenia; and Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist to treat gastroparesis, motion sickness, atopic dermatitis, and COVID-19 pneumonia.

The company's pipeline products also include VTR-297, a small molecule histone deacetylase inhibitor to treat hematologic malignancies and with potential use as a treatment for various oncology indications; VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist to treat performance anxiety and psychiatric disorders; VHX-896, an active metabolite of iloperidone; and antisense oligonucleotide molecules.

In addition, it offers a portfolio of cystic fibrosis transmembrane conductance regulator activators and inhibitors that include VSJ-110 for the treatment of dry eye and ocular inflammation; and VPO-227 for the treatment of secretory diarrhea disorders comprising cholera.

Vanda Pharmaceuticals Inc. was incorporated in 2002 and is headquartered in Washington, the District of Columbia.

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Before and After: A devastated art world wept and watched as Notre Dame burned
Before and After: A devastated art world wept and watched as Notre Dame burned
Apr 15, 2019
Notre Dame, a survivor of wars and revolutions, has stood for centuries as not merely the greatest of the Gothic cathedrals and a towering jewel of Western architecture. It has stood, in the words of one shell-shocked art expert, as "one of the great monuments to the best of civilization." And so it was that across the globe Monday, a stunned and helpless art world wept alongside the people of France as a massive fire ravaged the beloved cathedral. Construction on Notre Dame — French for "Our Lady" — began in the 12th century and continued for nearly 200 years. It sustained damage and fell into neglect during the French Revolution, but received renewed attention following the 1831 publication of Victor Hugo's novel "The Hunchback of Notre-Dame." This led to two decades of restorations, including the cathedral's famous flying buttresses and a reconstructed spire. While most kings were crowned elsewhere, Napoleon Bonaparte made sure he was crowned there in 1804, and married there in 1810. The exact cause of the blaze wasn't known, but French media quoted the fire brigade as saying it was "potentially linked" to a 6 million-euro ($6.8 million) renovation project on the church's spire and its 250 tons of lead. The Paris Prosecutor's office, which was investigating, said it was treating it as an accident. Aside from the structure, art experts were concerned about the fate of countless priceless artworks and artifacts inside, including relics like the crown of thorns, which is only occasionally displayed. The mourning was not limited to the art world. Religious leaders, too, expressed deep sorrow over the devastation. Those worried about the cathedral's durability could, perhaps, take solace in one of Notre Dame's more fascinating survival stories. In 1977, workers demolishing a wall in another part of Paris discovered 21 heads belonging to 13th-century statues from the cathedral. The kings of Judea, which were a prime example of Gothic art, had been taken from Notre Dame during the French Revolution and guillotined by antiroyalists who mistakenly thought they represented French kings
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