11:14 AM EDT, 04/21/2026 (MT Newswires) -- European equities traded in the US as American depositary receipts were falling sharply late Tuesday morning, dropping 1.15% to 1,812.72 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by petroleum refiner Equinor ( EQNR ) and internet browser company Opera (OPRA), which rose 2.7% and 1.7% respectively. They were followed by 3D printer company Materialise (MTLS) and medical device maker EDAP TMS ( EDAP ) , which were up 1.2% each.

The decliners from continental Europe were led by biopharmaceutical company argenx (ARGX) and pharmaceutical company Novo Nordisk ( NVO ) , which fell 3% and 2.8% respectively. They were followed by biotech firm Evaxion ( EVAX ) and pharmaceutical company Ascendis Pharma ( ASND ) , which were down 2.7% each.

The gainers from the UK were led by biopharmaceutical company Akari Therapeutics ( AKTX ) and software firm Endava ( DAVA ) , which advanced 6.4% and 2.7% respectively. They were followed by education company Pearson (PSO) and pharmaceutical company Silence Therapeutics ( SLN ) , which increased 1.2% and 0.9% respectively.

The decliners from the UK and Ireland were led by biopharmaceutical companies Biodexa Pharmaceuticals ( BDRX ) and NuCana ( NCNA ) , which dropped 8.7% and 3.2% respectively. They were followed by biopharmaceutical company Mereo BioPharma Group ( MREO ) and cruise line operator Carnival (CUK), which lost 2.3% and 2.2% respectively.