July 12 (Reuters) - The European Medicines Agency (EMA)
said on Friday patients taking weight-loss drugs such as Novo
Nordisk's Wegovy should inform their doctor ahead of
surgery, due to the risk of respiratory complications
potentially associated with such drugs.
Weight-loss drugs, including Wegovy and Eli Lilly's ( LLY )
Zepbound and Mounjaro, belong to a class known as GLP-1 receptor
agonists that slow the process of emptying food contents from
the stomach, making users feel full for longer.
So a patient taking such drugs could end up with a stomach
full of food on an operating table, despite fasting the night
before surgery, which could lead to a rare complication of
stomach contents moving into the respiratory tract, potentially
causing pneumonia.
However, the regulator said it had not yet found a causal
link between the GLP-1 drugs and the complication, called
aspiration.
The EMA's drug safety committee said the product information
of weight-loss drugs will be updated to include a warning to
patients that they should inform their doctor if they are
scheduled to undergo surgery under anesthesia or deep sedation.